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In our previous study, one candidate suscepti-bility locus for familial nasopharyngeal carcinoma (NPC) has been defined to a 14.21-cM region on 4p15.1-q12, whereas the distal minimum boundary of this region remained to be further determined in respect that the two markers D4S2996 and D4S428 were uninformative. In the present study, we carried out a haplotype analysis to identify the exact bound-ary by using the combination of a set of microsatellite mark-ers and single nucleotide polymorphism (SNP) markers in two major NPC families. We defined the exact distal bound-ary between D4S1577 and D4S3347, and consequently shortened the susceptibility locus to an 8.29-cM segment on 4p11-p14.
In our previous study, one candidate suscepti-bility locus for familial nasopharyngeal carcinoma (NPC) has been defined to a 14.21-cM region on 4p15.1-q12, whereas the distal minimum boundary of this region remained to be further determined in respect that the two markers D4S2996 and D4S428 were uninformative. In the present study, we carried out a haplotype analysis to identify the exact bound-ary by using the combination of a set of microsatellite mark-ers and single nucleotide polymorphism (SNP) markers in both major NPC families. We define the exact distal bound-ary between D4S1577 and D4S3347, and short of the susceptibility locus to an 8.29-cM segment on 4p11-p14.