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目的观察术前介入动脉栓塞化疗治疗中晚期宫颈癌的临床疗效和安全性。方法对2008～2011年收治的28例中晚期宫颈癌患者进行动脉栓塞化疗,1～2个疗程后行广泛子宫切除术及盆腔淋巴结清扫术,观察疗效和并发症。结果介入化疗后肿瘤所致疼痛、出血、下腹部坠胀等症均有不同程度的缓解;化疗所致并发症主要是胃肠道反应、下腹坠胀、低热等,对症处理或化疗结束可恢复;化疗总有效率达78.6%,临床获益率达92.9%;化疗后瘤体缩小或坏死,易切除,手术时间较短,术中出血量较少;预后分别完成1～3年的随访,生存率较高。结论术前介入动脉栓塞化疗可以缩小瘤体,使癌细胞发生不同程度坏死,利于瘤体切除和盆腔淋巴结清扫,可提高手术成功率。
Objective To observe the clinical efficacy and safety of preoperative interventional arterial chemoembolization in the treatment of advanced cervical cancer. Methods Twenty-eight patients with advanced cervical cancer who were treated from 2008 to 2011 were treated with arterial chemoembolization and extensive hysterectomy and pelvic lymphadenectomy were performed after one to two courses of treatment. Efficacy and complications were observed. Results The chemotherapy-induced pain, bleeding and bulging embolism in lower abdomen were all relieved to varying degrees. The complications caused by chemotherapy were mainly gastrointestinal reactions, bulging lower abdomen and fever, and the symptomatic treatment or the end of chemotherapy could be resumed ; The total effective rate of chemotherapy was 78.6%, and the clinical benefit rate was 92.9%; after the chemotherapy, the tumor was reduced or necrotic, easily resected, the operation time was short and the blood loss was less; the prognosis was completed in 1-3 years, Survival rate is higher. Conclusion Preoperative interventional arterial chemoembolization can reduce the size of the tumor and cause necrosis of the cancer cells to varying degrees, which is beneficial to tumor resection and pelvic lymph node dissection, which can improve the success rate of the operation.