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对２７例左向右分流先天性心脏病病人及１２例非癌症普胸病人，用放射免疫分析测定了血浆前列腺素Ｅ２（ＰＧＥ２），结果发现先心病肺高压组病人的血浆ＰＧＥ２（３２．０±５．２ｎｇ／Ｌ），显著高于无肺高压组（２３．０±４．４ｎｇ／Ｌ）及普胸对照组的（１９．１±３．９ｎｇ／Ｌ）；且轻度肺高压组（３０．９±４．８ｎｇ／Ｌ）及中重度肺高压组（３３．０±８．３ｎｇ／Ｌ）血浆ＰＧＥ２均显著高于无肺高压组的，而轻度肺高压组和中重度肺高压组血浆ＰＧＥ２比较，则差异不显著。先心病肺高压病人血浆ＰＧＥ２的增加，可能是对肺动脉压力升高的一种代偿机制，而肺动脉高压的发病是代偿不全及其它因素作用的结果。
Plasma prostaglandin E2 (PGE2) was measured by radioimmunoassay in 27 patients with left-to-right shunt congenital heart disease and 12 patients with non-cancer thromboembolism. The plasma PGE2 (32.0 ± 5.2ng / L), which was significantly higher than that of the non-pulmonary hypertension group (23.0 ± 4.4ng / L) and the general chest control group (19.1 ± 3.9ng / L) (30.9 ± 4.8ng / L), moderate and severe pulmonary hypertension group (33.0 ± 8.3ng / L), PGE2 were significantly higher than those without pulmonary hypertension group, and mild pulmonary hypertension group and moderate-severe lung Plasma PGE2 in high-pressure group, the difference was not significant. Pneumocardial hypertension in patients with congenital heart disease PGE2 increased, may be a compensatory mechanism of pulmonary hypertension, and the incidence of pulmonary hypertension is compensatory failure and other factors result.