纳洛酮是阿片受体拮抗剂,为羟二氢吗啡酮的衍生物,对调节感知与运动,睡眠与觉醒,心血管功能与呼吸运动等,起着神经递质和调节作用。随着对危重症病理生理的了解,纳洛酮作为阿片受体的纯拮抗剂,在儿科临床危重症抢救中得到了更广泛的应用。现综述如下。 1 应用基础 1.1 动物实验资料表明,脑缺血后,脑组织β-EP水平显著增高,并在脑内发挥其生物学效应,随后血浆的β-EP升高并产生生物学效应。而纳洛酮不仅 Naloxone, an opioid receptor antagonist, is a derivative of dihydroxymorphine and plays a neurotransmitter and regulatory role in regulating perception and exercise, sleep and wakefulness, cardiovascular function and respiratory activity. With the understanding of critical pathophysiology, naloxone, as a pure antagonist of opioid receptors, has been widely used in the treatment of pediatric clinical critically ill patients. Are summarized below. 1 Application of the basic 1.1 animal experimental data show that after cerebral ischemia, brain β-EP levels were significantly increased and its biological effects in the brain to play, followed by plasma β-EP increased and produce biological effects. And naloxone not only