Doxazosin为一α_1肾上腺素能受体阻滞剂。在人体内的清除半衰期较长,口服给药每日1次即可,健康人静脉注射时的清除半衰期为约9.5小时,血浆清除率为约每分钟88ml,分布容积为1L/kg,绝对生物利用度为约63％,蛋白结合率高达98.3％。在体内Doxazosin大部分通过氧化后经葡萄糖 Doxazosin is an alpha 1 adrenergic receptor blocker. The elimination half-life in the human body is longer, and can be administered orally once a day. The clearance half-life of the healthy human is about 9.5 hours after intravenous injection, the plasma clearance rate is about 88ml per minute, the distribution volume is 1L / kg, Utilization is about 63%, the protein binding rate as high as 98.3%. In vivo most of Doxazosin is oxidized by glucose