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目的:研究鮟鱇鱼骨多糖对去卵巢大鼠骨质疏松的作用,以确定鮟鱇鱼加工下脚料的使用价值,为进一步利用这一资源奠定基础。方法:通过切除大鼠双侧卵巢,建立去卵巢肥胖的动物模型;灌胃鮟鱇鱼骨多糖后处死大鼠,检测大鼠体重及脏器系数的变化情况,测定血清总胆固醇,甘油三酯,高密度脂蛋白,低密度脂蛋白的水平。结果:各给药组大鼠体重增长缓慢。总胆固醇,甘油三酯,低密度脂蛋白及动脉硬化指数手术组明显高于假手术组,鱼骨多糖组明显低于模型组。高密度脂蛋白和抗动脉硬化指数手术组显著低于假手术组,鱼骨多糖组显著高于模型组。各给药组大鼠肝脏、脂肪系数在不同程度上均低于模型组。结论:鮟鱇鱼骨多糖能明显抑制去卵巢大鼠体重的增加,降低血清总胆固醇、甘油三酯和低密度脂蛋白,增加高密度脂蛋白,是一种很好的保健材料。
OBJECTIVE: To study the effect of bream polysaccharide on osteoporosis in ovariectomized rats in order to determine the use value of scraps in processing bream catfish and lay a foundation for further utilization of this resource. Methods: The ovariectomized rats were established by ovariectomy. Ovariectomized rats were established by intragastric administration of bone polysaccharide. The changes of body weight and organ coefficient of rats were measured. The contents of total cholesterol, triglyceride, High-density lipoprotein, low-density lipoprotein levels. Results: The body weight of rats in each treatment group increased slowly. Total cholesterol, triglyceride, low density lipoprotein and arteriosclerosis index in the operation group were significantly higher than the sham operation group, fish bone polysaccharide group was significantly lower than the model group. High-density lipoprotein and anti-atherosclerosis index surgery group was significantly lower than the sham group, fish bone polysaccharide group was significantly higher than the model group. The liver and fat coefficient of rats in each administration group were all lower than the model group to varying degrees. Conclusion: Bone polysaccharide can significantly reduce the weight gain of ovariectomized rats, reduce serum total cholesterol, triglyceride and low density lipoprotein and increase high density lipoprotein, which is a good health care material.