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目的研究联合应用益生菌与柳氮磺吡啶治疗溃疡性结肠炎(ulcerative colitis,UC)的临床疗效。方法选取2013年7月—2014年7月收治的UC84例患者作为研究对象,随机分成治疗组和对照组各42例。治疗组接受益生菌联合柳氮磺吡啶治疗,对照组接受柳氮磺吡啶治疗,比较两组患者的临床疗效。计数资料进行χ2检验,P<0.05差异有统计学意义。结果观察组总有效率(95.24%)显著高于对照组(78.57%),组间比较差异有统计学意义(χ2=5.1362,P<0.05)。两组患者均无严重不良反应发生。结论益生菌联合柳氮磺吡啶治疗UC的效果显著,不良反应少,提高了患者的生活质量。
Objective To study the clinical efficacy of combined probiotics with sulfasalazine in the treatment of ulcerative colitis (UC). Methods A total of 84 UC patients admitted from July 2013 to July 2014 were randomly divided into treatment group (n = 42) and control group (n = 42). The treatment group received probiotics combined with sulfasalazine, the control group received sulfasalazine treatment, the clinical efficacy of the two groups were compared. Count data for χ2 test, P <0.05 difference was statistically significant. Results The total effective rate (95.24%) in the observation group was significantly higher than that in the control group (78.57%). The difference between the two groups was statistically significant (χ2 = 5.1362, P <0.05). No serious adverse reactions occurred in both groups. Conclusions Probiotics combined with sulfasalazine has a significant effect in the treatment of UC with fewer adverse reactions and improved patient quality of life.