从1989年Choo等首次克隆丙型肝炎病毒(HCV)cDNA成功以来,世界已对数十株HCV进行了克隆和测序,发现HCV变异较大存在多种亚型,HCV变异对肝炎发病机制、病原学诊断、疫苗研制及疾病治疗诸方面均有重要影响。1993年5月10-14日在日本东京召开第八届国际病毒性肝炎暨肝病研讨会,会上举行了“HCV分子变异及共临床意义”的专题研讨,这足以说明研究HCV变异的重要性,现就这次专题研讨内容综述如下: Since the first cloning of Hepatitis C virus (HCV) cDNA in 1989 by Choo et al., The world has screened and sequenced dozens of HCV strains and found that there are many subtypes of HCV with a large variation. HCV mutation affects the pathogenesis of hepatitis, pathogen Learning diagnosis, vaccine development and disease treatment have important implications. The 8th International Symposium on Viral Hepatitis and Liver Diseases was held in Tokyo, Japan on May 10-14, 1993, and the symposium on ”HCV Molecular Variation and Clinical Significance" was held, which is enough to illustrate the importance of studying HCV mutations Sex, now on the seminar are summarized as follows: