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观察40例孕13~24周自愿引产者服用米非司酮前后一般体检及生化指标、ECG改变;并监测胎动、胎心、羊水量的变化;死胎儿尸检并以光镜及电镜观察胎盘绒毛及蜕膜的变化.结果:母体各项指标无明显改变,但胎儿脐血示有肝、肾功能受损,部分病例有胎动、胎心、胎盘及羊水量异常改变,光镜及电镜显示胎盘呈灶性梗死、出血,绒毛细胞及蜕膜细胞变性,绒毛血管及蜕膜血管内皮细胞变性,管壁结构损伤.
The changes of general physical examination, biochemical indexes and ECG before and after taking mifepristone were observed in 40 pregnant women with voluntary induction of labor from 13 to 24 weeks of gestation. The changes of fetal heart rate, fetal heart rate and amniotic fluid volume were monitored. The autopsy of dead fetus was observed by light microscope and electron microscope. And decidual changes.Results: There was no significant change in maternal indicators, but the fetal cord blood showed liver and kidney dysfunction, some cases of fetal movement, fetal heart rate, placenta and amniotic fluid abnormal changes in light and electron microscopy showed placenta Focal infarction, hemorrhage, villi and decidual cells degeneration, villus and decidual vascular endothelial cell degeneration, wall structure damage.