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本文报道纯化的人类白细胞介素1(rIL-1)给予正常和照射小鼠辐射防护剂量20小时后对红细胞系和粒-巨噬集落形成细胞的影响.实验用B6D2F1雌性健康小鼠,12～14周龄,给药组腹腔注射rIL-15.6μg/kg,对照组注射0.5mL生理盐水,给药后20小时照射.~(60)Coγ线,剂量率0.4Gy/min,全身照射6.5、1.0和0.5Gy.结果:6.5Gy照后24小时,给药组与照射对照组的GM-CFC/股骨分别为非照射对照组的1.2±0.6%和1.0±0.3%,给药组经0.5Gy和0.1Gy照后二天,BFU-E/股骨,股骨与牌的CFU-E值均高于照射对照组.rIL-1和生理盐水注入后20小时,对脾细胞数无明显影响,然而rIL-1注射鼠每股骨细胞总数几乎是对照组骨髓细胞数的79%,每个股骨的GM-
The effect of purified human interleukin 1 (rIL-1) on the erythroid and granulocyte-macrophage colony forming cells after administration of radiation protection doses to normal and irradiated mice for 20 hours was reported in this study. The experimental B6D2F1 female healthy mice were used. At the age of 14 weeks, the administration group received intraperitoneal injection of rIL-15.6 μg/kg, and the control group was injected with 0.5 mL of physiological saline. The 60 Co γ line was irradiated 20 hours after administration, the dose rate was 0.4 Gy/min, and the whole body irradiation was 6.5 and 1.0. And 0.5 Gy. Results: 24 hours after 6.5 Gy irradiation, the GM-CFC/femur in the administration group and the irradiated control group were 1.2±0.6% and 1.0±0.3%, respectively, in the non-irradiated control group and 0.5 Gy in the administration group. After two days of 0.1Gy irradiation, the CFU-E values of BFU-E/femur, femur, and brand were higher than those of the irradiated control group. rIL-1 and saline were injected 20 hours after injection, but no significant effect on the spleen cell number, however, rIL-1 The total number of osteoblasts per mouse injected is almost 79% of the number of bone marrow cells in the control group, GM- of each femur