为复制妊娠高血压综合征动物模型，将清洁级Ｗｉｓｔａｒ大鼠随机分为３组，自妊娠第１５天起分别皮下注射生理盐水、亚硝基左旋精氨酸甲酯１２５ｍｇ／ｋｇ·ｄ和２５０ｍｇ／ｋｇ·ｄ，直到分娩。结果，孕鼠出现高血压、蛋白尿、肝肾功能与组织结构改变、及胎鼠发育迟缓等，类似妊娠高血压综合征，此外，尚出现胎鼠后肢畸形 In order to replicate the pregnancy induced hypertension syndrome model, Wistar rats were randomly divided into three groups: normal saline, nitroso-L-arginine methyl ester 125 mg / kg · d and 250 mg / Kg · d, until delivery. Results, pregnant rats appear high blood pressure, proteinuria, liver and kidney function and tissue structure changes, and fetal retardation, similar to pregnancy-induced hypertension syndrome, in addition, still appear fetal rat hindlimb deformity