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目的:观察免疫球蛋白配伍利巴韦林治疗轮状病毒性肠炎并脑炎的临床效果。方法轮状病毒性肠炎并脑炎56例,随机分为治疗组(28例)和对照组(28例)。对照组给予巴韦林(10-15mg.kg-1.d-1)、常规补液及支持治疗,治疗组在对照组的基础上给予免疫球蛋白(1000mg.kg-1.d-1),两组疗程均为3天。结果:治疗组和对照组有效率分别为89.2%和57.1%,治疗组疗效显著高于对照组(P<0.05)。结论:免疫球蛋白配伍利巴韦林治疗轮状病毒性肠炎并脑炎具有疗效好、起效快、副作用小等特点,建议临床推广。
Objective: To observe the clinical effect of immunoglobulin combined with ribavirin in the treatment of rotavirus enteritis and encephalitis. Methods Fifty-six patients with rotavirus enteritis and encephalitis were randomly divided into treatment group (28 cases) and control group (28 cases). The control group was given ribavirin (10-15mg.kg-1.d-1), routine rehydration and supportive therapy. The treatment group was given immunoglobulin (1000mg.kg-1.d-1) on the basis of the control group, The two groups were treated for 3 days. Results: The effective rates of treatment group and control group were 89.2% and 57.1%, respectively. The curative effect of the treatment group was significantly higher than that of the control group (P <0.05). Conclusion: Immunoglobulin combined with ribavirin for treatment of rotavirus enteritis and encephalitis has the advantages of good curative effect, fast onset of action and small side effects. It is suggested that clinical treatment should be promoted.