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将表面带正电荷的壳聚糖(CS)微球和表面带负电荷的聚(L-谷氨酸)-b-聚氧化丙烯-b-聚(L-谷氨酸)(GPG)胶束共混,制备了CS/GPG聚集体水溶液体系.通过改变CS/GPG的共混比例,研究了CS微球和GPG胶束形成稳定CS/GPG聚集体水溶液体系的配比范围,并对其粒径分布和表面电位进行了表征.在此基础上,将CS微球作为亲水性药物阿司匹林(Asp)的载体,GPG胶束作为疏水性药物阿霉素(DOX)的载体,通过多级自组装形成一种新型双重载药体系.研究了该双重药物载体的体外药物释放行为.结果表明,Asp和DOX都具有很好的药物缓释效果,并且2种药物的释药行为都具有明显的pH值响应性.
The surface positively charged chitosan (CS) microspheres and the surface negatively charged poly (L-glutamic acid) -b-polyoxypropylene-b-poly (L-glutamic acid) GPG micelles and CSGGPG aqueous solution.The CS / GPG copolymer aqueous solution system was prepared by changing the blend ratio of CS / GPG and the ratio of CS / Diameter distribution and surface potential. On this basis, CS microspheres were used as the carrier of hydrophilic drug Asp and GPG micelles were used as carrier of hydrophobic drug doxorubicin (DOX) Assembled to form a new dual drug-loading system.The in vitro drug release behavior of the dual drug carrier was studied.The results showed that both Asp and DOX had a good drug release effect and the drug release behavior of the two drugs were obvious pH responsiveness.