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目的:探讨可溶性血管内皮生长因子受体1(sFlt-1)和血管内皮生长因子(VEGF)对子痫前期的预测价值。方法:收治轻度子痫前期孕妇20例作为观察1组,收治重度子痫前期孕妇15例作为观察2组,选择正常孕妇10例作为对照组,检测3组血清和尿液sFlt-1和VEGF水平。结果:对照组血清、尿液sFlt-1水平低于观察1组、观察2组,而观察1组血清、尿液sFlt-1水平低于观察2组,差异具有统计学意义(P<0.01)。对照组血清、尿液VEGF水平高于观察1组、观察2组,而观察1组血清、尿液VEGF水平高于观察2组,差异具有统计学意义(P<0.01)。结论:血清和尿液sFlt-1和VEGF水平与子痫前期的病情程度具有一定的相关性,可作为临床预测指标。
Objective: To investigate the predictive value of soluble vascular endothelial growth factor receptor 1 (sFlt-1) and vascular endothelial growth factor (VEGF) in preeclampsia. Methods: Twenty pregnant women with mild preeclampsia were enrolled as observation group 1. Fifteen pregnant women with severe preeclampsia were treated as observation group 2. 10 normal pregnant women were selected as control group. Serum and urine sFlt-1 and VEGF Level. Results: The levels of sFlt-1 in serum and urine in the control group were lower than those in the observation group 1, and the levels of sFlt-1 in serum and urine in the observation group 1 were lower than those in the observation group 2 (P <0.01) . The level of VEGF in serum and urine in the control group was higher than that in the observation group 1, and the VEGF level in the serum and urine in the observation group 1 was higher than that in the observation group 2 (P <0.01). Conclusion: Serum and urine levels of sFlt-1 and VEGF have a certain correlation with the severity of preeclampsia and may be used as clinical predictors.