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目的探讨亲代出生体重对子代出生体重的影响及母亲宫内发育不良的经历是否会影响子代宫内发育状况,为研究环境和遗传因素对出生体重的影响提供线索。方法首都儿科研究所采用回顾性队列研究,于1995~2001年以1948~1954年北京协和医院出生的“宫内发育与成人疾病”队列人群为基础,利用研究对象的出生记录和回顾性问卷调查资料,分析出生体重在亲代与子代之间的关联。结果在控制了母亲的产次、生育年龄以及配偶的身高体重等影响因素后,母亲的出生体重与其子代出生体重之间存在显著的正相关关系(r=0·38,P<0·001),而父亲与子代之间在出生指标尚未表现出相关性;母亲为低出生体重(出生体重<2500g),其子代中低出生体重发生的危险是对照组(亲代出生体重≥3500g)的3倍多。结论母亲与子代在出生体重上存在明显正相关,母亲低出生体重可能会增加子代发生低出生体重的危险。
Objective To investigate whether the effect of birth weight on offspring ’s birth weight and the intrauterine dysplasia will affect the intrauterine development of offspring, and provide clues for studying the impact of environmental and genetic factors on birth weight. Methods A retrospective cohort study was conducted by the Capital Institute of Pediatrics. From 1995 to 2001, based on the “intrauterine growth and adult disease” cohort born at Peking Union Medical College Hospital in Beijing from 1948 to 1954, the birth record and retrospective questionnaire Data, analysis of birth weight in the relationship between parents and offspring. Results There was a significant positive correlation between mother’s birth weight and her offspring’s birth weight (r = 0.38, P <0.001) after controlling factors such as mother’s birth time, childbearing age and spouse’s height and weight. ), While the father and the offspring of the indicator of birth has not yet showed a correlation; the mother of low birth weight (birth weight <2500g), the risk of their children with low birth weight is the control group (birth weight ≥ 3500g) More than 3 times. Conclusion There is a clear and positive correlation between mother’s weight and offspring’s birth weight. Low mother’s weight may increase the risk of low birth weight in offspring.