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BNIP3是bc l-2家族中BH3-on ly亚家族的成员,具有BH3结构域和跨膜区,属于促凋亡蛋白。BNIP3通过促进线粒体通透性转运孔开放和线粒体的损伤诱导凋亡,其表达受缺氧和其他因素的影响。近年研究发现BNIP3的表达异常和许多肿瘤的进展及耐药性有关。
BNIP3 is a member of the BH3-on ly subfamily of the bc l-2 family, which has a BH3 domain and a transmembrane region and is a pro-apoptotic protein. BNIP3 induces apoptosis by promoting mitochondrial permeability transition pore opening and mitochondrial damage, whose expression is affected by hypoxia and other factors. Recent studies have shown that abnormal expression of BNIP3 and many tumor progression and drug resistance.