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目的：研究胰岛素抵抗（ＩｎｓｕｌｉｎＲｅｓｉｓｔａｎｃｅ，ＩＲ）与糖尿病性腔隙梗塞的关系。方法：对３４例非胰岛素依赖型糖尿病合并腔隙梗塞患者及３０例对照组患者进行了研究。分别测定了两组血胰岛素（Ｉｎｓ）、Ｃ肽（ＣＰ）、葡萄糖（Ｂｓ）、胆固醇（ＣＨＯＬ）和甘油三酯（ＴＧ）水平以及体重指数（ＢＭＩ）等指标。结果：糖尿病性腔隙梗塞组与对照组比较，其血Ｉｎｓ、ＣＰ水平明显升高，胰岛素敏感指数明显降低（Ｐ＜０．００１），其血ＣＨＯＬ、ＴＧ水平及ＢＭＩ亦升高（Ｐ＜０．０５）。结论：ＩＲ与糖尿病性腔隙梗塞有密切关系，ＩＲ是糖尿病性腔隙梗塞的独立危险因素之一，改善和治疗ＩＲ在预防糖尿病患者发生腔隙梗塞方面有重要作用
Objective: To investigate the relationship between insulin resistance (IR) and diabetic lacunar infarction. Methods: 34 patients with non-insulin-dependent diabetes mellitus complicated with lacunar infarction and 30 control subjects were studied. The levels of insulin, C peptide, Bs, CHOL and triglyceride (TG) and body mass index (BMI) were measured in the two groups. Results: Compared with the control group, the levels of blood Ins and CP in the diabetic lacunar infarction group were significantly increased and the insulin sensitivity index was significantly decreased (P <0.001). The levels of CHOL, TG and BMI were also increased (P < 0.05). Conclusion: IR is closely related to diabetic lacunar infarction. IR is an independent risk factor of diabetic lacunar infarction. Improving and treating IR plays an important role in preventing lacunar infarction in diabetic patients