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ALOX5AP位于染色体13q12-13,编码5-脂氧合酶激活蛋白(FLAP)。FLAP在调节白细胞三烯的形成中起关键作用。研究表明,携带此基因的人群患卒中的风险增高2倍。因此,ALOX5AP在卒中的发病机制中起着重要作用。
ALOX5AP is located on chromosome 13q12-13 and encodes 5-lipoxygenase activating protein (FLAP). FLAP plays a key role in regulating leukotriene formation. Studies show that people with this gene have a 2-fold increased risk of stroke. Therefore, ALOX5AP plays an important role in the pathogenesis of stroke.