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BACKGROUND:?The?timing?and?selection?of?patients?for?liver?transplantation?in?acute?liver?failure?are?great?challenges.?This?study? aimed? to? investigate? the? effect? of? Glasgow? coma? scale?(GCS)?and?APACHE-II?scores?on?liver?transplantation?outcomes?in?patients?with?acute?liver?failure. METHOD:?A?total?of?25?patients?with?acute?liver?failure?were?retrospectively? analyzed? according? to? age,? etiology,? time? to?transplantation,?coma?scores,?complications?and?mortality. RESULTS:?Eighteen? patients? received? transplants? from? live?donors?and?7?had?cadaveric?whole?liver?transplants.?The?mean?duration? of? follow-up? after? liver? transplantation? was? 39.86± 40.23? months.? Seven? patients? died? within? the? perioperative?period?and?the?1-,?3-,?5-year?survival?rates?of?the?patients?were?72%,?72%?and?60%,?respectively.?The?parameters?evaluated?for?the?perioperative?deaths?versus?alive?were?as?follows:?the?mean?age?of?the?patients?was?33.71?vs?28?years,?MELD?score?was?40?vs?32.66,?GCS?was?5.57?vs?10.16,?APACHE-II?score?was?23?vs?18.11,?serum?sodium?level?was?138.57?vs?138.44?mmol/L,?mean?waiting?time?before?the?operation?was?12?vs?5.16?days.?Low?GCS,?high?APACHE-II?score?and?longer?waiting?time?before?the?operation?(P