帕金森病(Parkinson’s disease,PD)是一种常见的慢性神经元退化性疾病。目前,PD的发病机制尚不清楚,为更好地理解其发病机制,我们通过建立PD的多种动物模型来模拟PD病的发病过程,为PD发病机制的研究提供实验依据。近年来有报道小胶质细胞是脑组织中主要的免疫细胞,在中枢神经系统免疫反应中起重要作用。小胶质细胞静息状态下对机体起到一定保护作用,但其长期慢性激活有神经毒性,对机体会造成损伤。在各种压力刺激下,小胶质细胞可被激 Parkinson’s disease (PD) is a common chronic neurodegenerative disease. At present, the pathogenesis of PD remains unclear. To better understand the pathogenesis of PD, we established a multi-animal model of PD to simulate the pathogenesis of PD and provide experimental evidence for the pathogenesis of PD. In recent years, it has been reported that microglial cells are the main immune cells in brain tissue and play an important role in the central nervous system immune response. Microglia resting state play a protective role on the body, but its long-term chronic activation of neurotoxicity, will cause damage to the body. In a variety of stress stimulation, microglia can be stimulated