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本研究探讨了将β-AP分别注入大鼠海马、隔核和基底巨细胞核后学习和记忆功能的变化。行为测试在β-AP注入 1周后进行。双侧海马 (背部 )注入β-AP后 ,大鼠的分辨学习能力明显下降 ,对照组达到学会标准所需的次数为 2 5± 10 .7;而β-AP组为3 6.7± 9.8,两组差别非常显著 (P<0 .0 0 5 ) .在注射 β-AP后每天给予 40 mg/kg(i.p.)的神经节苷脂 (GAs) ,连续 6d,则大鼠的学习能力可明显改善 ,达到标准所需次数为 2 6.3± 9.2。隔核内注入 β-AP后大鼠的分辨学习能力没有明显的变化 ,而一次性平台测试成绩明显下降 ,同样外源性神经节苷脂可改善这种记忆功能的损伤。本研究还观察了 β-AP注入基底巨细胞核所造成的工作记忆损伤以及 GAs对其的改善作用
This study investigated the changes of learning and memory function after β-AP were injected into hippocampus, septal and basal ganglia in rats respectively. Behavioral tests were performed 1 week after β-AP injection. After bilateral β-AP was injected into bilateral hippocampus, the resolving ability of rats decreased significantly, while that of control group reached 25 ± 10. 7, while that of β-AP group was 3 6.7 ± 9.8. (P <0.05) .Group 40 mg / kg (ip) of gangliosides (GAs) administered daily after β-AP injection for 6 days, the learning ability of rats can be significantly improved , The required number of times to meet the standard is 2 6.3 ± 9.2. There was no significant change in the learning ability of rats after intraperitoneal injection of β-AP, while the test scores of one-off platform decreased significantly. Similarly, exogenous gangliosides could improve this impairment of memory function. This study also observed the working memory impairment caused by β-AP injection into the giant cell nucleus and the effect of GAs on it