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目的研究不同血压水平与冠脉病变及临床事件之间的关系。方法收集我科行冠脉造影患者276例。根据患者血压状况分为血压正常组(82例),高血压Ⅰ级组(58例),高血压Ⅱ级组(65例),高血压Ⅲ级组(71例)。收集临床资料,冠脉评分采用改良的Gensini评分,分析各组冠状动脉造影结果及心脑血管事件发生率。结果各组冠脉病变程度构成比不同,血压正常组重度病变比例最低,高血压Ⅲ级组重度病变比例最高(P<0.05);多元逐步回归分析显示,年龄、吸烟、糖尿病、高血压均为Gensini评分的危险因素,高密度脂蛋白胆固醇为保护因素;随着血压的升高心脑血管事件发生率明显增高(P<0.05)。结论随着血压的升高,冠脉病变程度加重,心脑血管事件发生率增加。
Objective To study the relationship between different blood pressure levels and coronary artery disease and clinical events. Methods Collection of 276 cases of coronary angiography in our department. According to the patients’ blood pressure, they were divided into two groups: normotensive group (n = 82), hypertensive grade Ⅰ group (n = 58), hypertensive grade Ⅱ group (n = 65) and hypertensive grade Ⅲ group (n = 71). The clinical data were collected. The coronary score was evaluated by modified Gensini score and the results of coronary angiography and cardiovascular and cerebrovascular events were analyzed. Results The proportions of coronary lesions in each group were different. The proportion of severe lesion in normotensive group was the lowest, and the proportion of severe lesion in grade Ⅲ hypertensive group was the highest (P <0.05). Multiple stepwise regression analysis showed that age, smoking, diabetes and hypertension were Gensini score risk factors, high-density lipoprotein cholesterol as a protective factor; as the blood pressure increased cardiovascular and cerebrovascular events were significantly higher (P <0.05). Conclusion With the increase of blood pressure, the degree of coronary artery disease is increased, and the incidence of cardiovascular and cerebrovascular events is increased.