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近年来,经大量实验室、临床研究,表明一种或几种器官特异性肝细胞表面膜抗原可能具有重要的病理意义,包括慢性活动性肝炎(以下简称慢活肝)在内的某些肝病可能是对这些器官特异性抗原之一发生自身免疫反应的结果。 LSP 1972年,Meyer zum Büschenfelde等在人肝匀浆超速离心上清液中成功地提取了两种肝特异性抗原LPⅠ和LPⅡ,其中LPⅠ是分子量很大的低密度脂蛋白,来自肝细胞膜。他们用包含LPⅠ的肝抗原反复免疫家兔,兔肝脏
In recent years, a large number of laboratory and clinical studies have shown that one or more organ-specific hepatocyte surface antigen may have important pathological significance, including chronic active hepatitis (hereinafter referred to as slow living liver), including some liver disease It may be the result of an autoimmune response to one of these organ-specific antigens. LSP In 1972, Meyer zum Büschenfelde et al successfully extracted two kinds of liver-specific antigens, LPⅠ and LPⅡ, in human liver homogenate ultracentrifugation supernatant, in which LPⅠ is a high-molecular-weight low-density lipoprotein from the liver cell membrane. They repeatedly immunized rabbits and rabbit livers with LPI-containing liver antigens