胶质瘤是中枢神经系统发病率最高的恶性肿瘤,目前的治疗方法包括手术、放疗、化疗及生物免疫治疗,其中手术仍为最快速和有效去除肿瘤组织的手段。由于肿瘤常呈浸润性生长,术中肿瘤边界显示不清,要做到真正意义上的肿瘤“全切”非常困难。近年来发展起来的术中实时荧光显像技术可以提高肿瘤边界判断的准确性,有助于术者最大限度地切除肿瘤,改善患者预后。目前国际上相对成熟的荧光显像方法主要为荧光素钠和δ-氨基-γ-酮戊酸引导的荧光显像技术,其他荧光试剂如纳米荧光探针、靛氰绿等仍处于研究之中。 Glioma is a malignant tumor with the highest incidence of central nervous system. Current treatments include surgery, radiotherapy, chemotherapy and bioimmunotherapy. Surgery remains the fastest and most effective way to remove tumor tissue. Due to the often invasive growth of tumors, intraoperative tumor boundaries are not clear, to achieve a true sense of the tumor “all cut ” is very difficult. The intraoperative real-time fluorescence imaging developed in recent years can improve the accuracy of tumor boundary judgment, help the surgeon to maximally remove the tumor and improve the prognosis of the patients. At present, the relatively mature fluorescence imaging methods in the world are mainly fluorescent imaging techniques guided by sodium fluorescein and δ-amino-γ-keto-valeric acid. Other fluorescent reagents such as nano-fluorescent probes and indocyanine green are still under study .