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目的采用Meta分析的方法评价TNF-α基因中–308G/A位点多态性和前列腺癌易感性之间的关系,为进一步阐明前列腺癌发病的分子机制及筛查前列腺癌高风险人群提供参考。方法计算机检索PubMed(1950～2011)、EMbase(1990～2011)、CNKI、CBM、VIP和WanFang Data,按照纳入与排除标准筛出关于TNF-α-308位点多态性与前列腺癌相关性的病例-对照研究或队列研究,检索时限均为从建库至2012年1月。在提取数据和评价纳入研究的方法学质量后,采用RevMan 5.1.4和Stata 11.0软件进行统计分析。结果共纳入11个研究,4 919例前列腺癌患者,5 210例健康对照。Meta分析结果显示:①前列腺癌组与对照组中基因型AA vs.GG[OR=0.92,95%CI(0.71,1.20),P=0.55]、GA vs.GG[OR=1.11,95%CI(0.90,1.37),P=0.33)、AA vs.GG+GA[OR=0.91,95%CI(0.70,1.18),P=0.47)、GA+AA vs.GG[OR=1.11,95%CI(0.90,1.36),P=0.33)、等位基因A vs.G[OR=1.07,95%CI(0.91,1.26),P=0.39]与前列腺癌易感性之间均无相关性;②以人种为亚组进行分层分析,发现TNF-α–308位点的多样性在不同人种中也无明显相关性(P>0.05)。结论现有证据显示,TNF-α–308位点等位基因和基因型可能与前列腺癌易感性无关。由于纳入研究数量有限,上述结论尚需开展更多高质量、大样本的随机对照试验加以验证。
Objective To evaluate the relationship between the -308G / A polymorphism of TNF-α gene and the susceptibility to prostate cancer using Meta-analysis, and provide a reference for further elucidating the molecular mechanism of prostate cancer and screening for high-risk groups of prostate cancer . Methods PubMed (1950 ~ 2011), EMbase (1990 ~ 2011), CNKI, CBM, VIP and WanFang Data were searched by computer. According to inclusion and exclusion criteria, the relationship between TNF-α-308 locus polymorphism and prostate cancer Case-control study or cohort study, search time from the database to January 2012. After extracting data and evaluating the methodology quality of the included studies, statistical analysis was performed using RevMan 5.1.4 and Stata 11.0 software. Results A total of 11 studies were included, 4 919 cases of prostate cancer and 5 210 cases of healthy controls. The results of Meta analysis showed: (1) The genotypes AA vs. GG in prostate cancer group and control group were significantly higher than those in control group (OR = 0.92,95% CI 0.71,1.20, P = 0.55), GA vs.GG [OR = 1.11,95% CI (0.90, 1.37), P = 0.33), AA vs.GG + GA [OR = 0.91,95% CI 0.70,1.18, P = 0.47) (0.90,1.36), P = 0.33), allele A vs. G [OR = 1.07,95% CI (0.91,1.26), P = 0.39] had no correlation with susceptibility to prostate cancer; Ethnicity subgroups were stratified analysis and found that the diversity of TNF-α-308 loci in different ethnic groups also had no significant correlation (P> 0.05). Conclusion The available evidence shows that the TNF-α-308 locus allele and genotype may not be related to the susceptibility to prostate cancer. Due to the limited number of included studies, the above conclusion still needs to be verified by more high-quality, large-scale randomized controlled trials.