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去甲斑蝥素是临床常用抗肝癌药物,抗肿瘤作用强,并且具有保护肝细胞、提高免疫功能等作用。为提高其对肝脏的靶向性,降低对其他脏器的毒性,近年来不断有学者进行去甲斑蝥素主动肝靶向性药物的设计,如单克隆抗体导向药物、去唾液酸糖蛋白介导的药物等。本文综述了近十年来对去甲斑蝥素主动肝靶向性药物的研究进展,为开发应用于临床的去甲斑蝥素主动肝靶向性药物的研究提供参考。
Norcantharidin is commonly used in clinical anti-liver cancer drugs, anti-tumor effect, and has the protection of liver cells, improve immune function and so on. In order to improve its targeting to the liver and reduce the toxicity to other organs, in recent years, there have been some scholars for the design of norcantharidin active liver targeting drugs such as monoclonal antibody-directed drugs, asialoglycoprotein mediated Guide the drugs and so on. This review summarizes the research progress of norcantharidin active liver targeting drugs in the recent ten years and provides references for the development of clinical studies of norcantharidin active liver targeting drugs.