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重症脑卒中后应激性溃疡出血(SUB)的预防措施主要包括早期胃肠道内营养支持和药物预防。药物预防首选质子泵抑制剂(PPI),该类药物抑酸完全,持续时间长久。但过度抑酸可以影响食物的消化过程,延长食物在胃内的滞留时间,会导致胃内低酸或无酸,可引起胃内细菌过度增殖和影响一些营养成分的代谢、吸收。早期胃肠道内营养支持,则有助于PPI类药物对SUB的防治功效。因此,PPI和早期肠内营养支持的配伍治疗对重症脑卒中患者应激性溃疡的防治作用是目前重大课题,以期减少临床PPI使用的剂量以及缩短PPI使用的疗程。
Prevention of severe post-stroke stress ulcer bleeding (SUB) precautions include early gastrointestinal nutrition support and drug prevention. Proton pump inhibitor of choice for drug prevention (PPI), these drugs inhibit acid completely for a long time. However, excessive acid suppression can affect the digestive process of food, prolong the residence time of food in the stomach, can cause low or no acid in the stomach, can cause excessive proliferation of bacteria in the stomach and affect the metabolism of some nutrients, absorption. Early gastrointestinal nutrition support, then contribute to the prevention and treatment of SUBIs PPI drugs. Therefore, PPI and early enteral nutrition support for the prevention and treatment of stress ulcer in patients with severe stroke is a major issue at present, with a view to reducing the dose of clinical PPI use and shorten the course of PPI use.