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探讨人类白细胞抗原(HLA-DP,DQ,DR)在新疆哈萨克族食管鳞癌发生发展中的表达及其临床意义。采用免疫组织化学技术链霉素-过氧化物酶(S-P)法检测66例新疆哈萨克族食管鳞癌和28例正常食管粘膜组织(癌旁正常组织)中HLA-DP,DQ,DR抗原的表达。新疆哈族食管鳞癌组织中HLA-DP,DQ,DR抗原的阳性表达率为36.4%,高于正常对照组的7.1%(X~2=8.389,P<0.05);HLA-DP,DQ,DR抗原在食管癌中的表达与患者的年龄、性别、肿瘤生长部位、淋巴转移、分化程度无相关性。HLA-DP,DQ,DR的表达与新疆哈族食管鳞癌的发生发展密切相关。
To investigate the expression and clinical significance of human leukocyte antigen (HLA-DP, DQ, DR) in the occurrence and development of esophageal squamous cell carcinoma in Kazak of Xinjiang. The expression of HLA-DP, DQ and DR in 66 cases of esophageal squamous cell carcinoma of Xinjiang and 28 cases of normal esophageal mucosa (adjacent normal tissues) were detected by immunohistochemistry with streptavidin-peroxidase (SP) . The positive expression rate of HLA-DP, DQ and DR antigen in Kazakh Ha ethnic esophageal squamous cell carcinoma was 36.4%, which was 7.1% higher than that in the normal control group (X ~ 2 = 8.389, P <0.05) The expression of DR antigen in esophageal cancer had no correlation with the patient’s age, sex, tumor growth location, lymph node metastasis and differentiation degree. The expression of HLA-DP, DQ, DR is closely related to the occurrence and development of esophageal squamous cell carcinoma in Xinjiang Ha ethnicity.