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[目的]观察激素替代疗法(HRT)对去势、高脂饮食雌兔血脂的影响及对冠状动脉血管的病理形态学改变,为激素替代疗法提供血管病理形态学变化依据。[方法]以去势雌兔作为雌激素缺乏模型,喂食高脂饲料复制动脉粥样硬化症,并行HRT后测定兔血脂及光镜下观察冠状动脉血管病理形态学变化。32只兔共分为4组,每组8只,A假手术组;B模型组,行双侧卵巢切除术(OVX);C倍美力组,OVX后补充倍美力;D尼尔雌醇+安宫黄体酮组,OVX后补充尼尔雌醇+安宫黄体酮。[结果]各组兔TC、LDL-C、HDL-C指标与正常比较均有不同程度增高。各组与正常兔比较以上指标P﹤0.01;B、C、D与A组比较P﹤0.05;C、D与B组比较P﹥0.05。各组兔心脏各级冠状动脉血管均见不同程度早期动脉粥样硬化症病变,D组最轻,A组较轻,B组及C组较重。[结论]去势后HRT对兔血脂影响及冠状动脉粥样硬化病变的影响与雌激素类型、激素配伍使用有关。
[Objective] To observe the effects of hormone replacement therapy (HRT) on the blood lipids in ovariectomized and hyperlipidemic rabbits and the pathological changes of the coronary arteries, and provide basis for the changes of vascular pathomorphology for hormone replacement therapy. [Methods] The ovariectomized female rabbits were used as model of estrogen deficiency, high-fat diet was used to replicate atherosclerosis. Serum lipids were measured after HRT and pathological changes of coronary arteries were observed under light microscope. 32 rabbits were divided into 4 groups, 8 in each group, A sham operation group; B model group, bilateral ovariectomy (OVX); C Beverly group, OVX supplemented with Beverly; Alcohol + Andong progesterone group, after the addition of naloxolol + OVX progesterone progesterone. [Result] The TC, LDL-C and HDL-C indexes of rabbits in each group were all increased to some extent compared with the normal. The above indexes in each group were compared with normal rabbits, P <0.01; B, C and D were compared with those in group A, P <0.05; C and D were compared with those in group B, P> 0.05. Coronary artery blood vessels at all levels of rabbit in all groups showed varying degrees of early atherosclerosis lesions, the lightest in group D, the lighter in group A, and the heavier in group B and C. [Conclusion] The influence of HRT on the blood lipids and coronary atherosclerosis in post-castration patients is related to the type of estrogen and the compatibility of hormones.