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骨质疏松与衰老及许多代谢性疾病密切相关。绝经后妇女体内雌激素水平下降,糖皮质激素类药物的使用,以及航天飞行的失重效应均可诱导骨质疏松症的发生。氧化应激是骨质疏松发生的重要机制,自由基通过调控信号通路或诱发炎症反应影响成骨细胞及破骨细胞的分化、功能和凋亡,而抗氧化剂能有效预防和治疗骨质疏松症。线粒体作为细胞内能量代谢与氧化应激发生的主要部位,在骨质疏松的发生机制中发挥着重要作用,可能是防治骨质疏松症的新靶点。
Osteoporosis is closely related to aging and many metabolic diseases. Estrogen levels decline in postmenopausal women, the use of glucocorticoid drugs, and the weightless effects of aerospace flight can induce the occurrence of osteoporosis. Oxidative stress is an important mechanism of osteoporosis. Free radicals affect the differentiation, function and apoptosis of osteoblasts and osteoclasts through regulating signal pathway or inducing inflammatory reaction. Antioxidants can effectively prevent and treat osteoporosis . Mitochondria, as the main site of intracellular energy metabolism and oxidative stress, play an important role in the pathogenesis of osteoporosis and may be a new target of prevention and treatment of osteoporosis.