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以谷胱甘肽作为稳定剂,100℃恒温回流,直接合成水溶性CdTe量子点。基于Ag+对合成的CdTe量子点的荧光猝灭效应,建立了测定抗癌药物奥沙利铂中微量银的方法。考察了量子点浓度、缓冲液种类、缓冲液浓度、缓冲液pH和反应时间对银离子测定的影响。当量子点浓度为0.004 g/L时,在0.10 mmol/LpH7.4的磷酸缓冲溶液中,反应时间为5 min,体系的相对荧光强度与Ag+的质量浓度呈良好的线性关系,其线性范围为16.42～98.50μg/L,线性相关系数为0.9975,检出限为0.12μg/L。
With glutathione as a stabilizer, 100 ℃ constant temperature reflux, direct synthesis of water-soluble CdTe quantum dots. Based on the fluorescence quenching effect of Ag + on the synthesized CdTe quantum dots, a method for the determination of silver in the anti-cancer drug oxaliplatin was established. The effects of quantum dot concentration, buffer type, buffer concentration, buffer pH and reaction time on the determination of silver ion were investigated. When the quantum dot concentration was 0.004 g / L, the reaction time was 5 min in 0.10 mmol / L phosphate buffer solution pH 7.4, and the relative fluorescence intensity showed a good linear relationship with the mass concentration of Ag +. The linear range was 16.42 ~ 98.50μg / L, the linear correlation coefficient was 0.9975, the detection limit was 0.12μg / L.