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本文用放射免疫方法,测定了48例原发性慢性肾小球肾炎患者血浆6一Keto一PGF_(12)TXB_2的含量及T/6的比值,发现肾炎各型中血浆6一Keto—PGF_(12)含量均明显降低;TXB_2含量在肾病型明显增高,在肾功不全组明显降低。T/6比值在肾功正常各型中明显增高,在肾功不全组无明显改变。结果提示肾炎病变发展过程及,高凝状态的形成中,PCI_2-TXA_2的平衡失调起着重要的作用。为用能增加血浆中PGI_2或减少TXA_2产生的药物来治疗肾炎,提供依据。
In this paper, radioimmunoassay was used to determine the plasma levels of 6-Keto-PGF12 (12) TXB_2 and the ratio of T / 6 in 48 patients with primary chronic glomerulonephritis and found that plasma 6-Keto-PGF_ 12) levels were significantly lower; TXB_2 content increased significantly in nephropathy, renal insufficiency group was significantly lower. T / 6 ratio in all types of renal function was significantly higher in the renal insufficiency group did not change significantly. The results suggest that the progression of nephritis and hypercoagulable state formation, PCI 2-TXA 2 imbalance plays an important role. Provide a basis for the treatment of nephritis with drugs that increase plasma PGI 2 or reduce TXA 2 production.