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作者用抗凝疗法治疗10例活动性狼疮性肾炎(女8例,男2例,年龄19～46岁),其中7例有肾病综合征,6例有高血压,4例有肾功能衰竭,6例合并尿路感染。5例在抗凝前测定了血清纤维蛋白原降解产物,其含量均增高。9例经实验室检查证实为高凝血症和高纤维蛋白血症。作者的肝素用量为每次5000国际单位,一日4～6次,皮下或肌肉注射,并在凝血时间的监测下同时投给潘生了100～250毫克/日。3例长期应用细胞抑制剂。治疗结果:6例(肾病综合征4例)好转,肾病综合征的症象减轻或消失,尿症状减轻,肾功能改善。尤其是有弥漫性血管内凝血的临床—实验室表现者,效果尤为显著。3例无效,1例死于脑出血。
The authors used anticoagulant therapy to treat 10 cases of active lupus nephritis (8 females, 2 males, aged 19 to 46 years), of whom 7 had nephrotic syndrome, 6 had hypertension, 4 had renal failure, 6 cases with urinary tract infection. Serum fibrinogen degradation products were measured in 5 patients before anticoagulation, and their contents were increased. Nine patients confirmed hypercapnia and hyperfibrinogenemia by laboratory tests. The author’s heparin dosage for each 5000 IU, 4 to 6 times a day, subcutaneous or intramuscular injection, and coagulation time monitoring at the same time cast Pan born 100 to 250 mg / day. 3 cases of long-term use of cytostatics. Treatment results: 6 cases (nephrotic syndrome in 4 cases) improved, nephrotic syndrome symptoms reduced or disappeared, reduce the symptoms of urine, renal function improved. Especially those with diffuse intravascular coagulation clinical - laboratory performance, the effect is particularly significant. Three were ineffective and one died of cerebral hemorrhage.