目的建立妊娠前半期甲状腺激素参考值范围,为诊断、治疗孕妇甲状腺疾病提供参考。方法调查541例产科门诊就诊、进行甲状腺激素检查的健康孕妇,记录其甲状腺激素和甲状腺相关抗体检测结果;收集429例妊娠前半期正常孕妇甲状腺激素、尿碘,建立甲状腺激素参考值范围。参考值范围采用中位数(P50)及双侧限值(P2.5和P97.5)表示。结果妊娠前半期FT3、FT4和TSH中位数分别为4.72 pmol/L、15.61 pmol/L和1.63u IU/ml,参考值范围分别为3.53~6.68 pmol/L、11.15~22.81 pmol/L和0.09~5.06 u IU/ml。13~20周与0~12周比较FT3和FT4差异均有统计学意义(P<0.01),TSH和尿碘差异均差异无统计学意义(P>0.05)。结论建立妊娠前半期甲状腺激素参考值范围具有重要的临床意义。 Objective To establish a reference value range of thyroid hormone in the first half of pregnancy and provide a reference for diagnosis and treatment of thyroid disease in pregnant women. Methods A total of 541 pregnant women with obstetrics and gynecology clinic and thyroid hormone test were enrolled in the study. The thyroid hormone and thyroid-related antibodies were detected. 429 pregnant women with thyroid hormones and urinary iodine were collected during the first trimester of pregnancy. Thyroid hormone reference value was established. The reference range is expressed in terms of median (P50) and bilateral limits (P2.5 and P97.5). Results The median FT3, FT4 and TSH in the first trimester of pregnancy were 4.72 pmol / L, 15.61 pmol / L and 1.63u IU / ml respectively, and the reference values ​​ranged from 3.53 to 6.68 pmol / L, 11.15 to 22.81 pmol / L and 0.09 ~ 5.06 u IU / ml. The differences of FT3 and FT4 in 13-20 weeks and 0-12 weeks were statistically significant (P <0.01). There was no significant difference in the differences of TSH and urinary iodine (P> 0.05). Conclusion The establishment of reference range of thyroid hormone in the first half of pregnancy has important clinical significance.