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目的 :探讨抗Sa抗体检测对类风湿性关节炎 (RA)诊断意义。方法 :对75例RA患者和其它自身免疫性疾病患者 59例及健康正常人 47例血清 ,应用免疫印迹法检测抗Sa抗体和免疫胶乳凝集法检测类风湿因子 (RF)。结果 :抗Sa抗体对RA诊断敏感性为 42 .7% ,特异性为 1 0 0 % ,阳性确诊率为 1 0 0 % ,阴性确诊率为71 .2 % ;RF对RA诊断敏感性为 72 .0 % ,特异性为 79.2 % ,阳性确诊率为 71 .2 % ,阴性确诊率为 80 .0 %。结论 :抗Sa抗体检测对RA的辅助诊断价值优于RF
Objective: To investigate the anti-Sa antibody detection of rheumatoid arthritis (RA) diagnostic significance. Methods: Serum samples from 75 patients with RA and other autoimmune diseases and 47 healthy controls were tested for anti-Sa antibody and immune latex agglutination test for rheumatoid factor (RF) by Western blotting. Results: The sensitivity of anti-Sa antibody to RA diagnosis was 42.7%, the specificity was 100%, the positive diagnosis rate was 100% and the negative diagnosis rate was 71.2%. The sensitivity of RF to RA diagnosis was 72 .0%, the specificity was 79.2%, the positive diagnosis rate was 71.2%, the negative diagnosis rate was 80.0%. Conclusion: The anti-Sa antibody detection is superior to RF in the diagnosis of RA