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由于全球老龄化,射血分数保留的心力衰竭(heart failure with preserved ejection fraction,HFpEF)发生率持续上升。虽然HFpEF的病理生理机制仍然不完全清楚,但通常认为内皮炎症发挥了核心作用。细胞衰老是一种与老化和炎症有关的细胞生长停滞过程。Gevaert等使用加速老化的小鼠(senescence-
Due to global aging, the incidence of heart failure with preserved ejection fraction (HFpEF) continues to rise. Although the pathophysiology of HFpEF is still not fully understood, endothelial inflammation is often thought to play a central role. Cell Aging is a process of cell growth arrest associated with aging and inflammation. Gevaert et al use accelerated aging mice (senescence-