细胞抽提物重编程是近年来发展起来的技术,是将供体细胞抽提物导入受体细胞中,使受体细胞向供体细胞的形态、基因、功能等方面发生改变。目前,此方法已成功应用于体细胞与体细胞之间、体细胞与干细胞之间,成为一种有效的、无伦理学争议的重编程方法。本文就细胞抽提物重编程的研究现状、相关机理及存在的问题进行综述。 Reprogramming of cell extracts is a technique developed in recent years to introduce donor cell extracts into recipient cells and to change the morphology, gene and function of recipient cells into donor cells. At present, this method has been successfully applied to between somatic cells and somatic cells, between somatic cells and stem cells, becoming an effective and ethical controversial reprogramming method. This review summarizes the research status, related mechanisms and existing problems of cell extract reprogramming.