利用母体血清α-胎蛋白(AFP)筛选程序,能有效地评价单胎妊娠的开放性神经管缺陷(NTD)阳性检测率、假阳性率及阳性孕妇的受累优势,但对双胎妊娠仅能评价假阳性率,对受累双胎妊娠不能估评阳性孕妇的检测率和受累情况。为获得上述资料,作者收集分析了英国格拉斯哥等6所研究中心46对含1例以上开放性NTD的双胎妊娠资料,其中含1例无脑儿的20对,有1例开放性脊柱裂的23对,双胎受累者3对中无脑儿2例(1例结合性),开放性脊柱裂1例;用169例正常双胎作对照;两组均有孕13～24周的AFP检查结果。 The use of maternal serum a-fetoprotein (AFP) screening program can effectively evaluate the detection rate of open neural tube defects (NTD) in singleton pregnancies, the false positive rate and the prevalence of positive pregnant women, but only for twin pregnancies Evaluation of false positive rate, the affected twin pregnancy can not be assessed positive pregnant women detection rate and involvement. To obtain these data, the authors collected data from 46 research centers in six centers in Glasgow, UK, on ​​twin pregnancies containing more than one open NTD, including one of 20 pairs of children without cerebral brains and one with open spina bifida 23 pairs, 3 pairs of twin affected children without brain children in 2 cases (1 case of combination), open spina bifida in 1 case; with 169 normal twins as control; both groups were pregnant 13 to 24 weeks of AFP examination result.