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世界卫生组织推荐对被狂犬严重咬伤者联合使用狂犬病疫苗和抗狂犬病免疫球蛋白(HRIG)。但有人担心,被动抗体的输入可能会干扰主动抗体的产生。为此,作者进行了对照试验。 30名被动物咬伤的男性志愿者,年龄为30～54岁(平均37岁),未接种过狂犬病疫苗。将他们随机分为两组,每组15人。一组接种Merieux狂犬病疫苗;另一组接种Behringwerke疫苗。两种疫苗均为人二倍体细胞疫苗(HDCV),但Behringwerke疫苗经区带梯度离心提纯。所有受试者均按2-1-1程序进行免疫,即在第0、7和21天在三角肌
The World Health Organization recommends the use of rabies vaccine and anti-rabies immunoglobulin (HRIG) in rabies-severely bitten. However, some people worry that the input of passive antibodies may interfere with the production of active antibodies. To this end, the authors conducted a controlled trial. Thirty male volunteers were bitten by animals aged 30 to 54 years old (mean age 37 years) without rabies vaccination. They were randomly divided into two groups of 15 people each. One group received the Merieux rabies vaccine; the other group received the Behringwerke vaccine. Both vaccines are human diploid cell vaccines (HDCV), but Behringwerke vaccines are purified by zonal gradient centrifugation. All subjects were immunized according to the 2-1-1 procedure, ie, deltoid muscle on days 0, 7 and 21