论文部分内容阅读
目的探讨治疗2型糖尿病下肢动脉硬化闭塞症有效药物,改善患者生活质量。方法选择2型糖尿病并伴有不同程度下肢动脉硬化闭塞症临床症状患者38例,随机分为两组。在常规应用口服降糖药或胰岛素的基础治疗上,观察组加用盐酸丁咯地尔250 ml(盐酸丁咯地尔0.1 g)静脉滴注,1次/d;对照组以复方丹参注射液20 ml加入生理盐水250 ml中静脉滴注,1次/d。疗程均为4周。结果两组临床症状疗效比较观察组治疗总有效率95.5%,与对照组比较差异有统计学意义(P<0.01)。两组踝肱指数变化比较观察组治疗总有效率90.9%,与对照组比较差异有统计学意义(P<0.01)。结论盐酸丁咯地尔是一种治疗糖尿病下肢动脉硬化闭塞症的有效药物。
Objective To explore effective drugs for the treatment of type 2 diabetic lower extremity arteriosclerosis obliterans and to improve the quality of life of patients. Methods Thirty-eight patients with type 2 diabetes mellitus and clinical symptoms of lower extremity arteriosclerosis obliterans were randomly divided into two groups. In the routine application of oral hypoglycemic agents or insulin in the basic treatment, the observation group with buflomedil hydrochloride 250 ml (buflomedil hydrochloride 0.1 g), 1 / d; control group with compound Danshen injection 20 ml added saline 250 ml intravenous infusion, 1 time / d. The course of treatment is 4 weeks. Results The curative effect of clinical symptom in two groups was 95.5%, the difference between the two groups was statistically significant (P <0.01). The change of ankle-brachial index between the two groups showed that the total effective rate of the observation group was 90.9%, which was significantly different from that of the control group (P <0.01). Conclusion Buflomedil hydrochloride is an effective drug for the treatment of diabetic lower extremity arteriosclerosis obliterans.