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钒(V)的毒性作用早已为人们所认识,并进行了广泛的研究。钒化合物进入机体后,肾脏是其分布的主要部位。本文就钒在肾脏的代谢,钒对肾Na~+-K~+ATP酶的影响和对肾功能的影响以及可能的作用机制等方面予以综述。一、钒的代谢与肾脏生产环境中的钒主要经呼吸道进入体内。动物实验表明,钒进入体内后迅速分布到全身的各个器官,其中主要是肾脏,而且主要分布在肾皮质。Hockins等给大鼠一次静脉注射~(48)V,10分钟后,钒主要分布在血管丰富的器官,如心脏、肾脏和肺脏。而血管较少的器官如脑和睾丸则含钒较少。4天后,所有的器
The toxic effects of vanadium (V) have long been recognized and extensively studied. After the vanadium compound enters the body, the kidney is the main part of its distribution. This article reviews the metabolism of vanadium in the kidneys, the effects of vanadium on renal Na ~ + -K ~ + ATPase and its effects on renal function and its possible mechanism. First, vanadium metabolism and kidney production environment in the main vanadium into the body through the respiratory tract. Animal experiments show that vanadium into the body quickly distributed to various organs of the body, mainly the kidneys, but mainly in the renal cortex. Hockins et al once injected ~ (48) V into the vein of rats, and after 10 minutes, vanadium was mainly distributed in the blood-rich organs such as heart, kidney and lung. Less vascular organs such as the brain and testes contain less vanadium. After 4 days, all the devices