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致密核指数是指阴道涂片表层细胞有核固缩的百分数。Hutton1978年曾发现主诉经后性交困难的妇女比无症状的同龄妇女血浆雌二醇而不是雌酮的浓度明显降低。生殖道下端的严重萎缩是雌激素浓度减低的结果。本文目的是决定血浆雌激素浓度与致密核指数在原发性卵巢衰退患者中的关系。作者选择44例病人作阴道涂片,用95%酒精固定,巴氏染色。促性腺激素均在绝经期范围内,平均年龄56.0±8.8岁,从40～80岁;距末次月经7.4±9.2年,从0.2～30年。其中因涂片细胞数少于500个及因子宫脱垂,机械性刺激造成过度角化而不计算外,尚有38例。血浆雌二醇及雌酮浓度,通过血的双样品放射免疫法测定。
Dense nucleus index refers to the vaginal smears the surface cells nuclear pyknosis percentage. In Hutton in 1978, there was a downward trend in the concentration of women in the past few centuries. Serious atrophy of the lower genital tract is a result of reduced estrogen concentrations. The purpose of this paper is to determine the relationship between plasma estrogen concentration and dense nuclear index in patients with primary ovarian failure. The authors selected 44 patients for vaginal smear, fixed with 95% alcohol, pasteurized. Gonadotropins are in the menopause period, with an average age of 56.0 ± 8.8 years, from 40 to 80 years; from the last menstrual 7.4 ± 9.2 years, from 0.2 to 30 years. Among them, there are 38 cases because smear cell number is less than 500 and due to uterine prolapse and mechanical hyperkeratosis caused by mechanical stimulation. Plasma estradiol and estrone concentrations were determined by two-sample radioimmunoassay.