糖尿病肾病是微血管病变之一,是糖尿病死亡的主要原因。Davidson报告在1922年发现胰岛素以前,糖尿病患者死于糖尿病昏迷者占42～62％;死于糖尿病微血管病者占18～25％。胰岛素应用临床后,糖尿病昏迷病死率逐渐下降,微血管病病死率显著上升,最近统计前者为1％,后者为75％。又报告胰岛素依赖型糖尿病(首称IDDM)患者死亡原因分别为尿毒症80％,心肌梗塞10％;其它原因10％。IDDM约有30～35％并发糖尿病肾病,有50％IDDM儿童发病后平均20年内发生肾功能衰竭。据估计死 Diabetic nephropathy is one of the microvascular diseases, which is the main reason of diabetes death. Davidson reported that 42% to 62% of diabetic patients died of diabetic coma before they discovered insulin in 1922 and 18% to 25% of those who died of diabetic microvascular disease. Clinical application of insulin, diabetic coma mortality decreased gradually, microvascular disease mortality increased significantly, the latest statistics of the former was 1%, the latter was 75%. Also reported insulin-dependent diabetes (first IDDM) patients were uremia 80%, myocardial infarction 10%; other causes 10%. IDDM about 30 to 35% of diabetic nephropathy, 50% of children with IDDM onset of an average of 20 years after renal failure. It is estimated dead