近三年来应用超声技术筛查21-三体综合征(DS)一直有较大争议。通过文献回顾可评价超声检查在鉴别 DS 方面的前景。超声检查时 DS 可能出现以下图像:①胎儿畸形:与 DS 并存的某些特殊畸形有十二指肠闭锁、心脏、尿道畸形、脐疝、胸膜渗出等。但在妊娠24周以前,超声均难以发现,且上述畸形相对罕见, The use of ultrasound in the last three years to screen 21-trisomy syndrome (DS) has been the subject of considerable controversy. Literature review can evaluate the prospects of ultrasound in the identification of DS. DS ultrasound may appear the following images: ① fetal malformations: coexist with some DS with duodenal atresia, heart, urethral deformity, umbilical hernia, pleural exudation and so on. However, 24 weeks before pregnancy, ultrasound is difficult to find, and the above deformity is relatively rare,