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目的评价利奈唑胺注射液对老年重症感染性疾病的临床疗效及安全性。方法对2008年6月至2009年5月陕西省人民医院老年呼吸科使用利奈唑胺治疗的13例重症感染性疾病住院患者进行回顾性分析和总结。结果用药前13例患者均检出革兰阳性菌株,使用或换用利奈唑胺治疗,用药后清除13株(86.7%)。13例均在治疗后3～5d取得明显效果,有效率100%。有3例出现不良反应,其中1例有轻度呕吐,1例皮肤红疹,1例轻度腹泻。结论利奈唑胺可有效治疗老年重症感染性疾病,有些病例是在使用其他抗菌药物治疗效果不佳时换用利奈唑胺,患者耐受性良好,疗效确切。
Objective To evaluate the clinical efficacy and safety of linezolid injection in elderly patients with severe infectious diseases. Methods A retrospective analysis and summary of 13 inpatients with severe infectious diseases treated with linezolid in the Department of Geriatrics, Shaanxi Provincial People’s Hospital from June 2008 to May 2009 were conducted. Results Gram-positive strains were detected in 13 patients before treatment, with or without linezolid treatment, 13 (86.7%) were removed after treatment. 13 cases were 3 ~ 5d after treatment to achieve significant results, the efficiency of 100%. There were 3 cases of adverse reactions, including 1 case of mild vomiting, 1 case of skin rashes, 1 case of mild diarrhea. Conclusion Linezolid can effectively treat elderly patients with severe infectious diseases, and some cases use linezolid instead of other antibacterials. The patients are well tolerated and the curative effect is definite.