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目的通过对糖耐量试验和胰岛素释放试验的对比分析,探讨对2型糖尿病(T2DM)的诊断与治疗的临床意义。方法对内蒙古医学院附属人民医院新诊断T2DM服用药物治疗的患者123例和79例非糖尿病患者,服用100g馒头餐或75g葡萄糖粉,采用MAIA法(磁性分离酶联免疫法)测定胰岛素水平,氧化酶法测定糖耐量。按糖耐量测定结果分3组:糖耐量正常(NGT)组、糖耐量减低(IGT)组、T2DM组。结果T2TM空腹血糖、胰岛素明显高于NGT组,胰岛素在餐后2h达高峰,餐后3h不能恢复基础水平,二者曲线明显后移。结论IGT为胰岛素早期分泌受损,DM患者兼有严重的胰岛素抵抗(IR)和β细胞缺陷。
Objective To investigate the clinical significance of diagnosis and treatment of type 2 diabetes mellitus (T2DM) by comparing the glucose tolerance test and insulin release test. Methods 123 cases of patients with newly diagnosed T2DM in the People’s Hospital of Inner Mongolia Medical College and 79 cases of non-diabetic patients were treated with 100g steamed bread meal or 75g glucose powder. The levels of insulin were measured by MAIA (magnetic separation enzyme-linked immunosorbent assay) Enzymatic determination of glucose tolerance. The glucose tolerance test results were divided into 3 groups: normal glucose tolerance (NGT) group, impaired glucose tolerance (IGT) group, T2DM group. Results Fasting blood glucose and insulin in T2TM were significantly higher than those in NGT group. Insulin peaked at 2h after meal and could not recover to baseline level 3h after meal. Conclusion IGT is impaired in early insulin secretion, DM patients have both severe insulin resistance (IR) and β cell defects.