目的：了解大剂量１，２５（ＯＨ）２Ｄ３口服冲击对血透患者血清甲状旁腺素［ＰＴＨ（１～８４）］和血小板胞内游离钙浓度（Ｐｔ［Ｃａ２＋］ｉ）的影响和相互关系。方法：用Ｆｕｒａ２荧光测定法和免疫放射法对１２例血透患者测定Ｐｔ［Ｃａ２＋］ｉ和ＰＴＨ（１～８４）。结果：静息Ｐｔ［Ｃａ２＋］ｉ和ＰＴＨ（１～８４），治疗前是升高的，治疗后则降低；且两者密切相关，其Ｐ值治疗前＜０００１，治疗后＜００２５。多因素逐步回归显示：ＰＴＨ（１～８４）在Ｐｔ［Ｃａ２＋］ｉ的影响中起显著作用。结论：大剂量１，２５（ＯＨ）２Ｄ３冲击治疗能降低Ｐｔ［Ｃａ２＋］ｉ和ＰＴＨ（１～８４），其降低Ｐｔ［Ｃａ２＋］ｉ的作用可能是通过抑制ＰＴＨ合成与分泌 OBJECTIVE: To investigate the effects of high dose 1,25 (OH) 2D3 oral shock on serum parathyroid hormone (PTH) [1-84] and platelet intracellular free calcium concentration (Pt [Ca2 +] i) in hemodialysis patients . Methods: Pt [Ca2 +] i and PTH (1-84) were measured in 12 patients with hemodialysis using Fura2 fluorimetry and immunoradiography. Results: Resting Pt [Ca2 +] i and PTH (1 ~ 84) increased before treatment and decreased after treatment; and the two were closely related. The P value before treatment was less than 0001 and less than 0 after treatment 025. Multi-factor regression showed that PTH (1-84) played a significant role in the effect of Pt [Ca2 +] i. CONCLUSION: High-dose 1,25 (OH) 2D3 shock therapy can reduce Pt [Ca2 +] i and PTH (1-84), and its effect of decreasing Pt [Ca2 +] i may be through inhibition of PTH synthesis and secretion