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目的:分析超敏C反应蛋白(hs-CRP)与深静脉血栓形成(DVT)的相关性,探讨炎症反应在DVT发生及发展中的作用。方法:选取2013年9月至2015年3月我院收治的DVT患者113例,按病变部位分为中央型、周围型以及混合型,按发病时间分为急性期、亚急性期以及慢性期。另选取同期体检的健康志愿者50例作为对照组。检测所有研究对象血清hs-CRP水平。结果:DVT患者血浆hs-CRP高于正常健康人群(P<0.05);不同临床分型DVT患者血浆hs-CRP水平不同,混合型最高,周围型最低,差异具有统计学意义(P<0.05);不同发病时期DVT患者血浆hs-CRP水平不同,急性期最高,恢复期最低,差异具有统计学意义(P<0.05);接受溶栓治疗的DVT患者术后3天血浆hs-CRP水平持续升高,术后第5天开始快速下降。结论:hs-CRP可作为DVT诊断的参考指标,DVT发生及发展与炎症反应存在相关性。
Objective: To analyze the correlation between hs-CRP and DVT and to explore the role of inflammatory response in the development and progression of DVT. Methods: Thirty-one patients with DVT admitted to our hospital from September 2013 to March 2015 were divided into central type, peripheral type and mixed type according to the lesion. According to the time of onset, the patients were divided into acute, subacute and chronic phases. Another 50 healthy volunteers were selected as the control group. All subjects were tested for serum hs-CRP levels. Results: The plasma levels of hs-CRP in patients with DVT were significantly higher than those in healthy controls (P <0.05). The plasma levels of hs-CRP were different in different clinical categories of DVT patients, with the highest mixed type and the lowest peripheral type (P <0.05) ; The plasma levels of hs-CRP in different stages of DVT were different, with the highest in acute phase and the lowest in recovery phase (P <0.05). The plasma levels of hs-CRP continued to increase 3 days after DVT in patients receiving DVT High, the first five days after the rapid decline. Conclusion: hs-CRP can be used as a reference for the diagnosis of DVT. There is a correlation between the occurrence and development of DVT and inflammation.