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目的:探讨p28GANK在胰腺导管癌中表达及其临床意义。方法:用免疫组化法检测p28GANK在48例胰腺导管癌及其癌旁组织中的表达,分析p28GANK胰腺导管癌中表达与患者临床病理因素及术后生存率的关系。结果:p28GANK在胰腺导管癌组织中阳性表达率明显高于对应的癌旁组织(P<0.01);p28GANK在胰腺导管癌组织中高表达与高TNM分期、低级别分化程度、转移有关(均P<0.05),而与患者性别及年龄无关(均P>0.05)。p28GNAK阳性患者术后3年生存率明显低于阴性表达者(P=0.01)。结论:p28GANK在胰腺导管癌中表达上调,其高表达与患者恶性进展程度密切相关。
Objective: To investigate the expression of p28GANK in pancreatic ductal carcinoma and its clinical significance. Methods: The expression of p28GANK in 48 cases of pancreatic ductal carcinoma and its adjacent tissues was detected by immunohistochemistry. The relationship between the expression of p28GANK in pancreatic ductal carcinoma and the clinicopathological factors and postoperative survival rate was analyzed. Results: The positive rate of p28GANK in pancreatic ductal carcinoma was significantly higher than that in corresponding paracancerous tissues (P <0.01). The overexpression of p28GANK in pancreatic ductal carcinoma correlated with high TNM stage, low-grade differentiation and metastasis (all P < 0.05), but not with gender and age (all P> 0.05). The 3-year survival rate of patients with positive p28GNAK was significantly lower than that of patients with negative expression (P = 0.01). Conclusion: The expression of p28GANK is up-regulated in pancreatic ductal carcinomas. The high expression of p28GANK is closely related to the malignant progression of the patients.