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目的 研究肝功能异常伴抗可溶性肝抗原/肝胰抗原(SLA/LP)抗体阳性患者临床与实验 室特点。方法 收集肝功能异常患者血清5500例，分别完成相关自身抗体的检测。结果 8例(0．15%) 患者榆测出 SLA/LP 抗体阳性，女性6例，以中老年女性为主，男性2例，年龄分别为27岁和33岁，8例 中6例无甲、乙、丙、丁、戊型等病毒性肝炎现症感染证据，2例分别伴乙、丙型肝炎病毒标志物，无现症 感染证据。8例中7例已发展至肝硬化，除 SLA/LP 抗体阳性外，抗核抗体均为阳性，部分患者伴抗平滑肌 抗体，抗线粒体抗体，抗线粒体抗体亚型-丙酮酸脱氧酶复合物阳性。结论 SLA/LP 抗体在所检测患者 中阳性率较低，以女性患者为主，多数临床与实验室特点符合自身免疫性肝炎特征，女性患者慢性肝病原 因未名者应检测此抗体。
Objective To study the clinical and laboratory features of patients with positive liver dysfunction and anti-soluble liver antigen / hepatopancreas antigen (SLA / LP) antibody positive. Methods 5500 serum samples from patients with abnormal liver function were collected to detect the autoantibodies respectively. Results The SLA / LP antibody was detected in 8 cases (0.15%) of elm patients, 6 were female, mainly middle-aged and old women. There were 2 males, aged 27 and 33 years old, 6 of 8 without armor , B, C, D, E and other viral hepatitis evidence of infection, 2 cases were associated with hepatitis B and C virus markers, no evidence of infection. Seven of the eight patients developed cirrhosis and were positive for antinuclear antibodies except SLA / LP antibodies. Some patients had anti-smooth muscle antibodies, anti-mitochondrial antibodies, and anti-mitochondrial antibody subtypes-pyruvate dehydrogenase complex . Conclusions The positive rate of SLA / LP antibody in the tested patients is low, mainly in female patients. Most of the clinical and laboratory features are in line with the characteristics of autoimmune hepatitis, and the female patients with chronic liver diseases should be tested for this antibody.